Beta-Cross Laps Serum (β-СТх)

General information:

Β-Cross Laps (β-CTX) – a marker for bone resorption.
Beta - Cross Laps is a protein fragment that is formed as a result of the degradation of collagen I-type and is used as a marker for bone resorption. It is one of the indicators that are monitored during antiresorptive therapy (with bisphosphonates and hormone replacement therapy). in postmenopausal women treated for osteoporosis.

More than 90% of the organic bone matrix is composed of type I collagen synthesized in the bone. This matrix is subject to a continuous and well-regulated process of construction (formation) and degradation (resorption). During normal bone metabolism, mature type I collagen is degraded, small fragments of it enter the blood and are excreted through the kidney.

With physiologically or pathologically enhanced bone resorption (in old age or as a result of osteoporosis), collagen type I is degraded more intensively and, accordingly, the levels of collagen fragments in the blood increase. The measurement of these fragments is a marker of bone resorption, ie. a marker for assessing the activity of osteoclasts.

Sample required:

Venous blood, in morning in fasting