Immunoglobulin IgE total

 General information:

Immunoglobulin IgE plays an important role in mediating atopic reactions that occur when sensitized individuals are exposed to allergens. The majority of IgE molecules in serum bind to the surface of specific cells (mast cells and basophilic granulocytes). The interaction of allergens with cell-bound allergen-specific IgE causes these cells to release histamines and other vasoactive substances. In this way, an allergic reaction is triggered. Approximately 50% of people with allergic rhinitis or asthma have elevated IgE levels. However, there is a large number of people with allergy and elevated levels of IgE to specific allergens who have normal levels of total IgE. Studies have shown that total IgE levels are often elevated in patients with atopic dermatitis, and IgE concentration correlates with the severity of eczema. The level of total IgE may be elevated in patients with parasitic infections, allergic bronchopulmonary aspergillosis, or immunodeficiency. In all cases of suspected allergy, asthma, parasitic disease, eczema. After establishing elevated levels of IgE, antigen-specific IgE (panels for various allergens) are sought, if asthma (eosinophilic cationic protein) or parasitosis is suspected.

Sample required:

Venous blood

Key words:

Immunoglobulin IgE