Proinsulin intact

General information:

In the late stages of type 2 diabetes, proinsulin and proinsulin-like molecules are secreted in increasing amounts with insulin. This "intact" proinsulin, a marker of insulin resistance, induces an advanced stage of beta-cell reduced function. Insulin resistance is associated with a high risk of cardiovascular complications. This may be explained in part by direct insulin action on endothelial cells, but also by an independent contribution of beta-cell dysfunction. At a certain point, insulin requirements due to resistance increase, insufficiency of the enzymatic capacity of beta-carboxypeptidase H leads to increased secretion of intact proinsulin in addition to the required insulin molecule. Proinsulin stimulates plasminogen activator inhibitor-1 secretion and blocks fibrinolysis. Therefore, it is considered an independent risk factor for cardiac complications. It can be used as an additional test in the decision for therapy in type 2 diabetes and the subsequent treatment of patients.

Sample required:

Venous blood

Key words:

proinsulin intact