Central Laboratory
052 / 647 337

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53.50 BGN

General information:

Immunological marker in the diagnosis of diabetes mellitus along with anti-insulin antibodies (IAA), tyrosine phosphatase (IA-2Ab) antibodies and Zn T8 Antibodies to Zinc Transporter.
The attenuators against Langerhans' beta-cells (so-called autoantigens) appear before the clinical manifestation of diabetes. In childhood, they have a high concentration and are a predictor of the risk of type 1 diabetes. It is recommended to determine them for diagnosis and administration of insulin therapy.


Due to the long presence of anti-GAD-A (for years) and their predominance over ICA / IA2, the positive anti-GAD test appears to be the most reliable serologic marker for autoimmune insulin in adults (diagnostic sensitivity above 60%

Risk patients are:

  • patients with normal weight
  • age> 35 years
  • family story for Type 1 IP
  • insulin deficiency (reduced or low fasting plasma C-peptide levels and glucagon stimulation) without or with minimal insulin deficiency; decreasing BMI
  • low frequency of diabetes-related chronic complications or of markers of metabolic syndrome (arterial hypertension and dyslipidemia) in detecting the disorder in glucose
  • homeostasis and during the first 5 years after the diagnosis

For the confirmation of LADA, immunological parameters (screening for anti-GAD-A? And ICA) should be determined in these patients as well as the C-peptide
The high titer of anti-GAD-A? And positive multi-specific antibody assays are indicative of beta-cell stress / destruction and have been associated with decreased or low levels of plasma C-peptide which is a clearly detectable marker for decreased and declining beta- function.

SAMPLE REQUIRED:

Venous blood in the morning in fasting

 

 Key words:

Autoantibodies to Glutamate decarboxylase / GAD-65

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9000 Varna,

052 / 647 337 - клинична лаборатория, домашни посещения

052 / 647 227 - микробиология

0885 / 010 122 - молекулярна биология и микробиология

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9000 Varna,
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9000 Varna,
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9000 Varna,
"Asparuhovo"
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052 / 373 353

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Shopping center Chayka

0877 / 179 862

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Monday - Friday: 07:30 - 16:30
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9000 Varna,
267 Vladislav Varnenchik boulevard
MC Haelan Care 4

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9000 Varna,
Briz, Knyaz Boris I 135

0879 / 381 922

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9000 Varna,
3 "Hristo Smirnenski" str.
VMA, fl. 2, cab. 25

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