anti - TPO + Anti - TG

General information:

TPO antibodies are directed against the thyroid peroxidase and are identical to the MAT antibodies. They inhibit enzyme activity, disrupt thyroid tissue and block its function, which is clinically manifested as hypothyroidism. They are usually high before the appearance of the clinical signs of the disease. They are most often positively influenced by Hashimoto's thyroiditis. In addition, they are not only highly sensitive but also highly specific. Their research is also recommended for other autoimmune diseases of the gland, as well as prolonged treatment with amiodarone, IFNα, IL-2 and lithium. It is important to follow in Down syndrome, and in obstetric practice with suspected thyroid dysfunction during pregnancy, postpartum thyroiditis, spontaneous abortion and in vitro fertilization.

Diseases of the thyroid gland should be tracked over time by hormones and specific markers. Some of the diseases of the gland are with autoimmune genesis, which means that antibodies are formed against their own tissues (in the case of thyroid agents).

Thioglobulin antibodies (Tg Ab, TAT) are directed against thyroglobulin. It is a protein that is synthesized by thyroid cells (thyrocytes). This protein has a key role in the synthesis of thyroid hormones. When antibodies are directed against thyroglobulin, its function is disturbed. TATs have an important diagnostic value in thyroid autoimmune diseases but can not displace the burden of TPO antibodies. TAT are less sensitive, but their research is still needed. The levels of both TPO and TAT should be established jointly for the appropriate diagnosis. Hashimoto's thyroiditis is positivised in 60% of cases, in Basemal disease - 30% and in subtype thyroiditis - 10-20%.

 Sample required:

Venous blood in morning in fasting

Key words:

thyroid, anti tpo, anti tg