Thalassemia (HbA2 + HbF)

General information:

Thalassemia is a hereditary disorder, a type of anaemia that breaks the haemoglobin polypeptide chain synthesis (respectively, there is no or reduced synthesis of a - or b -Globin chains). According to which chain is affected, alpha and beta-thalassemia differ.

Thalassemia occurs among the populations of the Mediterranean, Africa, Asia, and mostly in southern Bulgaria.

More frequent is beta-thalassemia and it is better studied. As a result of an inherited genetic defect, the synthesis of b-globin chains is disturbed and this leads to the inadequate synthesis of Hemoglobin A1, which is the highest percentage of healthy elderly people. The decrease in haemoglobin A1 in erythrocytes is associated with an increase in Fetal Hemoglobin (F) and Hemoglobin A2. As a result, the changed percentages of Hemoglobins: A1, A2 and F, erythrocytes have a reduced haemoglobin content and a tendency to more rapid rupture - this is the mechanism of anaemia.

Sample Required:

Venous blood in the morning in fasting

Keywords:

Thalassemia, HbA2 + HbF, hemoglobin, A1, A2, F, anemia