Coagulation factor 8 Ag + Ristoc. Cofactor

General information:

This factor binds factor VIII, a key protein in blood clotting, and platelets in the walls of the blood vessels, which is essential during the blood clotting process. Von Willebrand's disease (VWD) is a genetic disease with a deficiency or total lack of this factor. It is encountered in equal proportions in men and women and is the most common disease related to coagulation factors.
Patients complain of frequent nose bleeds (> 10 min), easy bruising, and prolonged and increased bleeding in various procedures (tooth extraction, surgery), blood in the urine and faeces. Women have severe menstrual cycles, birth bleeding, anemia, fatigue, frequent breathlessness.
There are 3 types of VWD, inherited and differing in quantitative and qualitative defects. There is a fourth non-hereditary.

• Type 1 in 60-80% of patients, mild symptoms, the defect is quantitative, and factor levels vary between 20-50% of the normal
• Type 2 in 15-30% of patients, qualitative changes in the factor, this type is divided into four subtypes, the symptoms are mild to moderate.
• Type 3 in 5-10% of patients, quantitative serious bleeding deficiency in joints, ligaments and internal organs

Acquired form: in atomic diseases (lupus), GCC, cancer, after receiving medication, only adults are affected.

In diagnosis, VWD subtypes 2A and 2M. Both types are quantitative and both types express the factors to some extent: RCo weak. Specialized in-depth study to determine the type of haemophilia and subsequent treatment.
Specialized in-depth study to determine the type of haemophilia and subsequent treatment.

Sample required:

Venous blood in the morning in fasting

Key words:

Coagulation factor 8 Willebrand