Direct Bilirubin

General information:

Bilirubin is the main pigment in the bile juice. Daily around 250-300 mg of bilirubin are formed in the human body. About 80% of this amount originates from the degradation of haemoglobin released by the degradation of obsolete erythrocytes. The remaining 15-20% of the formed bilirubin is the result of the degradation of heme-containing enzymes (cytochromes, catalases, peroxidases), myoglobin, and so on.

The elevation of total bilirubin over 30-35 μmol / l results in bilirubin deposition in the tissues and yellow staining of skin, sclera and mucous membranes. Jaundice (icterus) is exactly this yellow colouration as a result of bilirubin deposition in tissues. Upon elevation of serum bilirubin between 22-35 μmol / l, some people may notice a slightly yellowish sclera stain, referred to as a subcutter. Jaundice is a leading, though sometimes late, a symptom in most liver diseases, bile ducts, haemolytic anaemias, and many inherited and acquired disorders of bilirubin metabolism.

Sample Required:

Venous blood in the morning in fasting

Keywords:

Direct bilirubin, jaundice, enzymes, liver diseases