General information:

Factor V Leiden is a variant form of the factor V protein that arises due to the presence of a common genetic point mutation, a change in one of the nucleotides on the gene that codes for the production of factor V protein. This altered Factor V Leiden protein activates normally to participate in stimulating blood coagulation, but resists being degraded by the anticoagulant activated protein C (APC) and thus remains active for longer than the wild type Factor V protein. The result of this resistance is an increased level of thrombin in the blood which is associated with a higher risk of venous thromboembolism (VTE)

Sample reqired:

Venous blood

Key words:

Factor 5, Leiden